What version of Denemo? Did you compile from source? I believe the binary packages for MacOS X have not worked for quite some time.
As I wrote earlier to this list, I would like to package Denemo for Mac OS X as I know there is much interest in the program on this platform, but I also have a limited background in computer programming and I think I should prioritize learning and using Denemo first (which also serves to test Denemo on Mac). My optimistic timeline is probably end of year for binary packages, and about three months for a MacPorts source distribution.