diff --git a/gnu/packages/gnupg.scm b/gnu/packages/gnupg.scm
index dc801a6a4..a20dd9928 100644
--- a/gnu/packages/gnupg.scm
+++ b/gnu/packages/gnupg.scm
@@ -402,7 +402,8 @@ and every application benefits from this.")
               (uri (pypi-uri "gpg" version))
               (sha256
                (base32
-                "1x74i6q713c0bckls7rdm8kgsmllf9qvy9x62jghszlhgjkyh9nd"))))
+                "1x74i6q713c0bckls7rdm8kgsmllf9qvy9x62jghszlhgjkyh9nd"))
+              (patches (search-patches "python-gpg-add-largefile-cflags.patch"))))
     (build-system python-build-system)
     (arguments
      '(#:tests? #f)) ; No test suite.
diff --git a/gnu/packages/patches/python-gpg-add-largefile-cflags.patch b/gnu/packages/patches/python-gpg-add-largefile-cflags.patch
new file mode 100644
index 000000000..e57efe307
--- /dev/null
+++ b/gnu/packages/patches/python-gpg-add-largefile-cflags.patch
@@ -0,0 +1,12 @@
+--- gpg-1.8.0-old/setup.py      2016-11-30 04:41:41.000000000 -0500
++++ gpg-1.8.0/setup.py  2017-01-08 15:13:20.437996702 -0500
+@@ -34,6 +34,9 @@
+ extra_swig_opts = []
+ extra_macros = dict()
+
++# force largefile support
++extra_macros.update({"_FILE_OFFSET_BITS": 64, "_LARGEFILE_SOURCE": 1})
++
+ if os.path.exists("../../src/gpgme-config"):
+     # In-tree build.
+     in_tree = True